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Introduction

We are the British Library Science Team; we provide access to world-leading scientific information resources, manage UK DataCite and run science events and exhibitions. This blog highlights a variety of the activities we are involved with. Follow us on Twitter: @ScienceBL. Read more

07 April 2015

The Importance of Understanding Number Entry

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EThOS at the British Library and our partners Research Councils UK and Vitae recently ran our inaugural #ShareMyThesis competition. The competition challenged PhD students past or present to summarize why their research is/was important in 140 characters or less. For more information see the competition webpage here.

The overall winner was Sarah Wiseman who succinctly conveyed the importance of her PhD research at UCL in the following tweet:

Here we re-post Sarah’s winning article:

Have you ever dialled a phone number incorrectly and ended up talking to the wrong person on the end of the line? Most people have, and it can be a little embarrassing (although occasionally it has been known to result in romance). Now, have you ever typed a number wrongly when setting up a bank transfer? That’s a bit more annoying, and many people have lost a lot of money by sending it to the wrong person. But that’s only money. Sometimes the consequences of number entry error can be even more severe: when a doctor or nurse types a number incorrectly into a medical device the patient can receive a serious overdose. This, unfortunately, is not a rare occurrence, and there are regularly cases reported in the news of a number entry error resulting in the harm or even death of a patient.

Often in the media the response is to blame the nurse or doctor for being sloppy. This reaction means that medical workers can themselves become victims of the incident as they are portrayed as being solely responsible for the otherwise avoidable death of a patient.

Although they have different consequences, the reasons we make errors when typing numbers in the hospital is no different from when we dial the wrong phone number. Sometimes we just make an error when entering numbers because humans are fallible and are even more so when asked to work in high-stress environments such as the hospital. Blaming the medical workers involved in these cases will not help to prevent future errors from happening.

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Image:Shutterstock

One way to reduce the number of these tragic incidents from occurring is to improve the design of medical devices. It has been shown that some number entry interfaces found on medical devices, such as those used to administer drugs to patients, can be unpredictable. Other interfaces obscure key numbers from users, making it difficult for them to notice any errors they’ve made. In safety critical situations it is important the device interfaces are as intuitive and easy to use as possible.These systems are poorly designed partly because we haven’t understood how people type numbers. It is for this reason that I focussed on understanding how users transcribe numbers in my PhD thesis. During my research I was able to show that there are patterns in the numbers entered by medical workers when programming some devices, and that these patterns affect the way that the numbers are transcribed. These common numbers have so far been overlooked when testing number entry interfaces. By incorporating this information into the testing process, interfaces can be examined in more realistic ways.

It isn’t just testing practices that could be improved however; the design of the number entry interfaces themselves can also be altered. Further research in my PhD showed that adapting the interfaces to match these regularly used numbers significantly reduced the number of key presses required, which could reduce the opportunity for error.

These were just a few insights from my PhD work, but they highlight that current practices in number entry research and design stand to be updated and improved. Knowing more about the number entry task can allow for more thorough and accurate testing of interfaces. This would mean that they could be made as error proof as possible. Hopefully by incorporating the number entry research that both myself and others are doing, medical devices in the future can be designed with the user in mind. In doing so we might be able to reduce the occurrence of avoidable, and life altering errors.

Sarah completed her PhD with Anna Cox at UCL’s Interaction Centre. Her work was funded by UCL Psychology and Languages Department with additional funding from EPSRC through the CHI+MED project. Her thesis is available here. Sarah is now working as a post doctoral researcher based at both University College London and the Open University. At the OU she is working on a project that aims to explore how technology can improve accessibility to the arts for people with visual impairments. At UCL she is continuing her PhD topic by researching number entry error and the possible causes.

01 April 2015

A Medieval Medical Marvel

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A medieval potion, described in a 1000 year-old manuscript kept at the British Library, has recently been shown to have 'astonishing' antibiotic properties, capable of defeating the 'superbug' MRSA. Boudewijn Dominicus looks at the science behind this 'ancientbiotic'.

Medieval medicine is often seen as a bit of an oxymoron. With practices such as bloodletting commonplace1, many would say this reputation is deserved. Indeed the word for ‘leech’, a creature synonymous with medicine of the era, is derived from the Anglo-Saxon word for physician ‘laece2.

Sloane Bloodletting
Bloodletting was a common panacea, a therapy to 'rebalance the humours'.
Image: © The British Library Board (Folio 11v, Le Regime du corps)

Although many treatments were ineffective or even harmful, careful analysis of Old English medical texts has revealed that not all of them were as backwards as we imagine. For example, there is evidence that honey was used as an antiseptic – its high sugar content and low levels of hydrogen peroxide destroying bacterial cells3.  Another example was the use of the herb marrabium vulgare (horehound) to treat coughs – horehound is still used today in some throat lozenges4. Some of these treatments required specific identification of herbs, careful preparation and appropriate administration. Such examples show that Anglo-Saxon physicians were willing to experiment, see what worked and from that, occasionally, find an effective cure – formulating simple compound drugs using a prototypical scientific method.

But now, researchers from the University of Nottingham have discovered a medieval treatment for eye infections which puts even some modern medicines to shame. The eye salve described in Bald’s Leechbook, a 9th century medical manuscript held by the British Library, was tested by a team of microbiologists at Nottingham University’s Centre for Biomolecular Sciences and was shown to kill one of today’s most notorious antibiotic-resistant bacteria: Methicillin-resistant Staphylococcus aureus (MRSA).

Bald's Leechbook Folio 12b
Bald's Leechbook was the preeminant medical text of its day.
Image: © The British Library Board (Royal 12 D xvii)

Dr Christina Lee, an Anglo-Saxon expert from the University’s School of English, translated the recipe which was made from a mixture of garlic, onions, wine, and bovine bile salts, all of which were then brewed in a brass cauldron and let sit for nine days:

“take cropleek and garlic, of both equal quantities, pound them well together, take wine and bullocks’ gall, of both equal quantities, mix with the leek, put this then into a brazen vessel, let it stand nine days in the brass vessel, wring out through a cloth and clear it well, put it into a horn, and about night time apply it with a feather to the eye.”

The microbiologists made three batches and tested them on cultures of three commonly found and hard to treat bacteria, Staphylococcus aureus, Staphylococcus epidermidis and Pseudomonas aeruginosa in both synthetic wounds and in infected wounds in mice. The results were then compared to a control treatment using the same recipe, but without the vegetable compounds. On their own the ingredients had no measureable effect, but when combined the mixture was startling effective: only about one in a thousand bacteria survived application. Vancomycin, the current antibiotic of choice against MRSA, has approximately the same level of antibacterial activity.

The scientists then diluted the eye salve, investigating its effectiveness at different concentrations and exploring its possible mechanism of action. Interestingly, they found that when the medicine was too dilute to kill Staphylococcus aureus, it interfered with bacterial cell-cell communication (quorum sensing). Quorum sensing is essential to the formation of biofilms; a means by which bacteria aggregate together to form a cell colony. Biofilms can promote bacterial antibiotic resistance by forming a dense outer film around a colony which is impervious to antimicrobials such as antibiotics and detergents. As such, many microbiologists think that blocking this behaviour could be a means of combatting antibiotic resistance. 

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Colonies of bacteria, such as Pseudomonas aeruginosa (shown above), defend themselves by grouping together and secreting adhesive polymers to form a 'biofilm'.
Image: Public Domain (Janice Carr, CDC)

Bald’s remedy certainly confirms that this approach is promising. Many of the microbiologists involved were surprised by the efficacy of the treatment. Dr Freya Harrison, who led the work in the laboratory at Nottingham, commented that they were “hopeful that Bald’s eyesalve might show some antibiotic activity, because each of the ingredients has been shown by other researchers to have some effect on bacteria in the lab – copper and bile salts can kill bacteria, and the garlic family of plants make chemicals that interfere with the bacteria’s ability to damage infected tissues. But we were absolutely blown away by just how effective the combination of ingredients was.”

The next step is to investigate why the combination confers such powerful antibiotic activity; in isolation each individual ingredient has little effect. Understanding how and why these ingredients interact may inform the development of new drugs which could help us combat theevil that is antibiotic resistance’.

 

Boudewijn Dominicus

References

1http://britishlibrary.typepad.co.uk/digitisedmanuscripts/2013/10/anglo-saxon-medicine.html

2http://bjgp.org/content/bjgp/20/97/63.full.pdf

3http://europepmc.org/abstract/MED/23569748

4http://www.vikingsofmiddleengland.co.uk/surgery-medicine.html

31 March 2015

Access to Understanding 2015: In Summary

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The winners of the Access to Understanding science writing competition are revealed.

On Friday 27 March, under the striking façade of the King’s Library Tower, the British Library played host to the Access to Understanding Awards 2015. The event was a celebration of excellent science writing: an evening to recognise the efforts and accomplishments of our entrants and also, more broadly, to recognise the value of clear science communication. But before we reflect on the evening’s festivities, first we take a look back at the competition as a whole.

The competition is run in partnership by The British Library, eLife and Europe PMC. We asked entrants to write a summary of a research article at a level that an interested member of the public would understand. Each summary needed to explain why the research was done, what was done and why it was important, all in fewer than 800 words. Entrants could choose from twelve articles, freely available from Europe PMC.

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Looking back at the competition...

Now in its third year, the competition has gone from strength to strength. We received over 300 entries and a record number of votes were cast for the People’s Choice Award (1604). If ever evidence were needed that there is a demand for plain-English science, from both the public and the scientific community, then Access to Understanding provides it.

The need for plain-English science summaries was further underlined by Professor Jim Smith, Deputy CEO of the MRC, in his keynote speech where he stated that “such summaries would be a huge contribution to our attempts to explain science and its significance”. He felt that, in combination with further open access publishing, “this democratisation of science is very important, [perhaps] the most radical change in science communication since… the first journal 350 years ago.” Simon Denegri, NIHR National Director for Patients and the Public in Research and chair of our judging panel, echoed the importance of plain-English science in his speech emphasising that “the knowledge gained from good [science] writing is empowering”.

Jim Smith keynote
Professor Jim Smith giving his keynote speech

Now, our shortlist represents some of the best plain-English science writing around, but who was the best?

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Our shortlist (from left to right): Sabrina Talukdar (People's Choice), Elizabeth Randall, Hannah Ralph, Hannah Mackay, Carly Lawler, Natalie Edelman, Minghao Chia, Peter Canning (3rd), David Bowkett, Philippa Matthews (1st), Sophie Regnault, and chair of our judging panel Simon Denegri.

First place was awarded to Philippa Matthews for her entry ‘Rolling back malaria: A journey through space and time’, which described research exploring the changing patterns of malaria risk across Africa. Second place went to Juliet Lamb for her entry ‘Who you are, or who you’re with? Age predicts disease risk’. And third place was awarded to Peter Canning for his entry ‘Breaking through cancer’s acid shell’ which discussed drug absorption in the acidic environment around tumours. The People’s Choice Award – a key part of our competition – was won by Sabrina Talukdar for her entry ‘The persistent perils of puberty’. For more on these winning entries, please check out our previous blog announcing the competition winners.

Winners
Our winners (clockwise from top left): Peter Canning (3rd), Philippa Matthews (1st) and Sabrina Talukdar (People's Choice)

These Pulitzers of plain-English science are the culmination of several months of hard work – by entrants, funders and judges alike – without them there would be no competition. We’d like to thank everyone involved for their efforts and we look forward to doing it all over again in 2016!