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Discover Science at the British Library

Introduction

We are the British Library Science Team; we provide access to world-leading scientific information resources, manage UK DataCite and run science events and exhibitions. This blog highlights a variety of the activities we are involved with. Follow us on Twitter: @ScienceBL. Read more

15 May 2015

To survive we must explore

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If you couldn’t make it to our most recent TalkScience event fear not. The latest instalment in our TalkScience series is now available on YouTube for your viewing pleasure.

In the 28th event of our popular series we discussed what we have learnt from doing science in extreme environments, and if it is worth the high financial and human cost. The event was chaired by author and broadcaster Dr Gabrielle Walker who kindly stepped in at the last minute. Our expert speakers were Professor Jane Francis, Dr Michael Bravo and Dr Kevin Fong.

As ever the debate was thoughtful and wide ranging. We discussed how extreme environments affect the scientists' ability to actually do the research, and debated whether the development of new technologies is reducing the need for humans in future explorations. We were also privileged to hear our four panellists’ personal experiences of doing science in extreme environments. Jane Francis shared a particularly memorable experience: When she first started researching in the Antarctic female researchers had to wear men’s thermal underwear as female specific kit was not available. As the first female director of the British Antarctic Survey, Jane was pleased to report that this is no longer the case! There was also interest from the audience on the issue of diversity in extreme science. Although historically exploration has been the preserve of white males this is certainly not the case nowadays.

 

We also discussed the unexpected serendipity of historic data informing the present and the challenge of doing extreme science when many projects with more tangible and immediate benefits lack funding. Kevin Fong spoke of his own internal conflict when going to NASA to discuss plans for a multibillion pound mission to Mars while back home he was working in intensive care units where they desperately needed an extra dialysis machine.

At the end of the evening our four panellists were in broad agreement about the importance of extreme exploration with Kevin pithily summing up with:

“To explore we must survive but, as a species, to survive we must explore”.

We are currently hatching plans for TalkScience 29 which will take place at the end of June. Check back soon to find out more.

 Katie Howe

07 April 2015

The Importance of Understanding Number Entry

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EThOS at the British Library and our partners Research Councils UK and Vitae recently ran our inaugural #ShareMyThesis competition. The competition challenged PhD students past or present to summarize why their research is/was important in 140 characters or less. For more information see the competition webpage here.

The overall winner was Sarah Wiseman who succinctly conveyed the importance of her PhD research at UCL in the following tweet:

Here we re-post Sarah’s winning article:

Have you ever dialled a phone number incorrectly and ended up talking to the wrong person on the end of the line? Most people have, and it can be a little embarrassing (although occasionally it has been known to result in romance). Now, have you ever typed a number wrongly when setting up a bank transfer? That’s a bit more annoying, and many people have lost a lot of money by sending it to the wrong person. But that’s only money. Sometimes the consequences of number entry error can be even more severe: when a doctor or nurse types a number incorrectly into a medical device the patient can receive a serious overdose. This, unfortunately, is not a rare occurrence, and there are regularly cases reported in the news of a number entry error resulting in the harm or even death of a patient.

Often in the media the response is to blame the nurse or doctor for being sloppy. This reaction means that medical workers can themselves become victims of the incident as they are portrayed as being solely responsible for the otherwise avoidable death of a patient.

Although they have different consequences, the reasons we make errors when typing numbers in the hospital is no different from when we dial the wrong phone number. Sometimes we just make an error when entering numbers because humans are fallible and are even more so when asked to work in high-stress environments such as the hospital. Blaming the medical workers involved in these cases will not help to prevent future errors from happening.

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Image:Shutterstock

One way to reduce the number of these tragic incidents from occurring is to improve the design of medical devices. It has been shown that some number entry interfaces found on medical devices, such as those used to administer drugs to patients, can be unpredictable. Other interfaces obscure key numbers from users, making it difficult for them to notice any errors they’ve made. In safety critical situations it is important the device interfaces are as intuitive and easy to use as possible.These systems are poorly designed partly because we haven’t understood how people type numbers. It is for this reason that I focussed on understanding how users transcribe numbers in my PhD thesis. During my research I was able to show that there are patterns in the numbers entered by medical workers when programming some devices, and that these patterns affect the way that the numbers are transcribed. These common numbers have so far been overlooked when testing number entry interfaces. By incorporating this information into the testing process, interfaces can be examined in more realistic ways.

It isn’t just testing practices that could be improved however; the design of the number entry interfaces themselves can also be altered. Further research in my PhD showed that adapting the interfaces to match these regularly used numbers significantly reduced the number of key presses required, which could reduce the opportunity for error.

These were just a few insights from my PhD work, but they highlight that current practices in number entry research and design stand to be updated and improved. Knowing more about the number entry task can allow for more thorough and accurate testing of interfaces. This would mean that they could be made as error proof as possible. Hopefully by incorporating the number entry research that both myself and others are doing, medical devices in the future can be designed with the user in mind. In doing so we might be able to reduce the occurrence of avoidable, and life altering errors.

Sarah completed her PhD with Anna Cox at UCL’s Interaction Centre. Her work was funded by UCL Psychology and Languages Department with additional funding from EPSRC through the CHI+MED project. Her thesis is available here. Sarah is now working as a post doctoral researcher based at both University College London and the Open University. At the OU she is working on a project that aims to explore how technology can improve accessibility to the arts for people with visual impairments. At UCL she is continuing her PhD topic by researching number entry error and the possible causes.

01 April 2015

A Medieval Medical Marvel

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A medieval potion, described in a 1000 year-old manuscript kept at the British Library, has recently been shown to have 'astonishing' antibiotic properties, capable of defeating the 'superbug' MRSA. Boudewijn Dominicus looks at the science behind this 'ancientbiotic'.

Medieval medicine is often seen as a bit of an oxymoron. With practices such as bloodletting commonplace1, many would say this reputation is deserved. Indeed the word for ‘leech’, a creature synonymous with medicine of the era, is derived from the Anglo-Saxon word for physician ‘laece2.

Sloane Bloodletting
Bloodletting was a common panacea, a therapy to 'rebalance the humours'.
Image: © The British Library Board (Folio 11v, Le Regime du corps)

Although many treatments were ineffective or even harmful, careful analysis of Old English medical texts has revealed that not all of them were as backwards as we imagine. For example, there is evidence that honey was used as an antiseptic – its high sugar content and low levels of hydrogen peroxide destroying bacterial cells3.  Another example was the use of the herb marrabium vulgare (horehound) to treat coughs – horehound is still used today in some throat lozenges4. Some of these treatments required specific identification of herbs, careful preparation and appropriate administration. Such examples show that Anglo-Saxon physicians were willing to experiment, see what worked and from that, occasionally, find an effective cure – formulating simple compound drugs using a prototypical scientific method.

But now, researchers from the University of Nottingham have discovered a medieval treatment for eye infections which puts even some modern medicines to shame. The eye salve described in Bald’s Leechbook, a 9th century medical manuscript held by the British Library, was tested by a team of microbiologists at Nottingham University’s Centre for Biomolecular Sciences and was shown to kill one of today’s most notorious antibiotic-resistant bacteria: Methicillin-resistant Staphylococcus aureus (MRSA).

Bald's Leechbook Folio 12b
Bald's Leechbook was the preeminent medical text of its day.
Image: © The British Library Board (Royal 12 D xvii)

Dr Christina Lee, an Anglo-Saxon expert from the University’s School of English, translated the recipe which was made from a mixture of garlic, onions, wine, and bovine bile salts, all of which were then brewed in a brass cauldron and let sit for nine days:

“take cropleek and garlic, of both equal quantities, pound them well together, take wine and bullocks’ gall, of both equal quantities, mix with the leek, put this then into a brazen vessel, let it stand nine days in the brass vessel, wring out through a cloth and clear it well, put it into a horn, and about night time apply it with a feather to the eye.”

The microbiologists made three batches and tested them on cultures of three commonly found and hard to treat bacteria, Staphylococcus aureus, Staphylococcus epidermidis and Pseudomonas aeruginosa in both synthetic wounds and in infected wounds in mice. The results were then compared to a control treatment using the same recipe, but without the vegetable compounds. On their own the ingredients had no measureable effect, but when combined the mixture was startling effective: only about one in a thousand bacteria survived application. Vancomycin, the current antibiotic of choice against MRSA, has approximately the same level of antibacterial activity.

The scientists then diluted the eye salve, investigating its effectiveness at different concentrations and exploring its possible mechanism of action. Interestingly, they found that when the medicine was too dilute to kill Staphylococcus aureus, it interfered with bacterial cell-cell communication (quorum sensing). Quorum sensing is essential to the formation of biofilms; a means by which bacteria aggregate together to form a cell colony. Biofilms can promote bacterial antibiotic resistance by forming a dense outer film around a colony which is impervious to antimicrobials such as antibiotics and detergents. As such, many microbiologists think that blocking this behaviour could be a means of combatting antibiotic resistance. 

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Colonies of bacteria, such as Pseudomonas aeruginosa (shown above), defend themselves by grouping together and secreting adhesive polymers to form a 'biofilm'.
Image: Public Domain (Janice Carr, CDC)

Bald’s remedy certainly confirms that this approach is promising. Many of the microbiologists involved were surprised by the efficacy of the treatment. Dr Freya Harrison, who led the work in the laboratory at Nottingham, commented that they were “hopeful that Bald’s eyesalve might show some antibiotic activity, because each of the ingredients has been shown by other researchers to have some effect on bacteria in the lab – copper and bile salts can kill bacteria, and the garlic family of plants make chemicals that interfere with the bacteria’s ability to damage infected tissues. But we were absolutely blown away by just how effective the combination of ingredients was.”

The next step is to investigate why the combination confers such powerful antibiotic activity; in isolation each individual ingredient has little effect. Understanding how and why these ingredients interact may inform the development of new drugs which could help us combat theevil that is antibiotic resistance’.

 

Boudewijn Dominicus

References

1http://britishlibrary.typepad.co.uk/digitisedmanuscripts/2013/10/anglo-saxon-medicine.html

2http://bjgp.org/content/bjgp/20/97/63.full.pdf

3http://europepmc.org/abstract/MED/23569748

4http://www.vikingsofmiddleengland.co.uk/surgery-medicine.html